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Medicin
2012-04-23
Lunds universitet


New stem cell found in the brain


Researchers at Lund University have discovered a new stem cell in the adult brain. These cells can proliferate and form several different cell types - most importantly, they can form new brain cells.
Now the researchers hope to put the discovery to use to develop methods that can repair diseases and injury to the brain.

Analysing brain tissue from biopsies, the researchers for the first time found stem cells located
around small blood vessels in the brain. The cell’s specific function is still unclear, but its plastic
properties suggest great potential. A similar cell type has been identified in several other organs where it can promote regeneration of muscle, bone, cartilage and adipose tissue.

In other organs, researchers have shown clear evidence that these types of cells contribute to
repair and wound healing. Scientists suggest that the curative properties may also apply to the
brain. The next step is to try to control and enhance stem cell self-healing properties with the aim
of carrying out therapies targeted to a specific area of the brain.
“Our findings show that the cell capacity is much larger than we originally thought, and that
these cells are very versatile,” said Gesine Paul-Visse, Ph.D., Associate Professor of Neuroscience at Lund University.
“Most interesting is their ability to form neuronal cells, but they can also be developed for other cell types. The results contribute to better understanding of how brain cell plasticity works and opens up new opportunities to exploit these very features.”

The study, published in the journal PLoS ONE, is of interest to a broad spectrum of brain
research. Future possible therapeutic targets range from neurodegenerative diseases to stroke.

“We hope that our findings may lead to a new and better understanding of the brain's own repair
mechanisms,” said Dr. Paul-Visse. “Ultimately the goal is to strengthen these mechanisms and
develop new treatments that can repair the diseased brain.”

Link to the study here:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0035577

The study:
Title: The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells
Published in: PLoS ONE, 16 April, 2012.

Contact:
Gesine Paul-Visse, Reader, Neurologist, Department of Clinical Sciences in Lund, Lund University
Tel: 046-177766, 046-2220524 Gesine.Paul-Visse@med.lu.se
Jens Persson