The study was led by Professor Ernest Arenas and demonstrates that the formation of dopamine-producing neurons during brain development in mice is dependent on the activation of a specific receptor in the brain by an oxidised form of cholesterol called oxysterol. Dopamine-producing nerve cells play an important part in many brain functions and processes, from motor skills to reward systems and dependency. They are also the type of cell that dies in Parkinsonâs disease.
The scientists have also shown that embryonic stem cells cultivated in the laboratory, form more dopamine-producing nerve cells if they are treated with oxidised cholesterol. The same treatment also reduced the tendency of the stem cells to show uncontrolled growth.
âOxysterol contributes to a safer and better cultivation of dopamine-producing cells, which is a great advancement since it increases the possibility of developing new treatments for Parkinsonâs disease,â says Professor Arenas.
It is hoped that one day it will be possible to replace dead cells in the brains of Parkinsonâs patients with transplanted cultivated dopamine-producing cells. Such cells can also be used to test new Parkinsonâs drugs.
Publication: âLiver X Receptors and oxysterols promote ventral midbrain neurogenesis
in vivo and in human embryonic stem cellsâ, Paola Sacchetti, Kyle M. Sousa, Anita C. Hall, Isabel Liste, Knut R. Steffensen, Spyridon Theofilopoulos, Clare L. Parish, Carin Hazenberg, Lars Ăhrlund Richter, Outi Hovatta, Jan-Ă
ke Gustafsson & Ernest Arenas, Cell Stem Cell, 2 October 2009.
For further information, please contact:
Professor Ernest Arenas
Department of medical biochemistry and biophysics
Tel: +46 (0)8 524 876 63 or +46 (0)8-524 876 94 (lab)
Mobile: +46 (0)70 2456663
Email: ernest.arenas@ki.se
Professor Outi Hovatta
Department for clinical science, intervention and technology
Tel: +46 (0)8-58583858
Mobile: +358-(0)5051135
Email: outi.hovatta@ki.se
Press Officer Katarina Sternudd
Tel: +46 (0)8-524 838 95
Email: katarina.sternudd@ki.se
Karolinska Institutet is one of the leading medical universities in Europe. Through research and education, Karolinska Institutet contributes to improving human health. Each year, the Nobel Assembly at Karolinska Institutet awards the Nobel Prize in Physiology or Medicine. For more information, visit ki.se
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