The so-called CASCADE Network of Excellence, coordinated from Swedish Karolinska Institutet, had its first meeting in Malaga, Spain, February 12th – 14th. Around 70 scientists, EU officials, and other invited project leaders met and discussed an appropriate course of action for the future. It was agreed that CASCADE has the potential and goal to be a world force in knowledge on the health issues related to chemical contaminants in food.

The focus will lie on the action of complex mixtures of chemical contaminants on hormonal systems. Hormone disrupting agents, acting through nuclear receptors, are known to be involved in many different pathological processes, such as tumour development and growth, metabolic disease and obesity, and coronary heart disease; in short the major diseases that affect Europeans today.

In this initial 5-year contract, the molecular biologists, chemists, epidemiologists, ecotoxicologists, physiologists and endocrinologists of CASCADE will focus on the mechanisms of action of the chemical residues and their levels in the food chain, development of common sampling techniques, and identification of biological markers to assess any health risks the contaminants might constitute for humans. Specific focus groups will be women, newborn children and other susceptible populations.

A new approach will be to develop strategies to take any beneficial effects of certain natural food constituents into consideration in the overall risk analysis.

“We are extremely excited over this opportunity to participate in the establishment of a new and highly competitive infrastructure for European research in the area of food toxicology” says coordinator Professor Jan-Åke Gustafsson at the Department of Biosciences at the South Campus of Karolinska Institutet, Huddinge.

Vice-coordinator Ingemar Pongratz adds “This is not another research project. We are gluing 16 institutes and 2 companies into one unity. No single country has enough competence by itself to solve the problem.”

Results will include training programmes and provision of rationalised information to society for a balanced risk assessment of food contaminants. Various national and international organisations have already been associated to the network to reinforce the contacts between CASCADE and the outside world. In annual open fora, CASCADE will communicate scientific achievements of the network to the public, to authorities, and to organisations associated to the network as observers.

Funding
CASCADE is funded through the European Commission, Sixth Framework Programme, Thematic Area 5: Food Quality and Safety. CASCADE is being provided €14.4 million over 5 years for its scientific, integration, teaching, information, and risk assessment activities.

For further information contact:
Ingemar Pongratz, Ph.D.,vice-coordinator, Department of Biosciences at Novum, Karolinska Institutet, Sweden, phone +46 8 608 91 13, email ingemar.pongratz@biosci.ki.se

Jan-Åke Gustafsson, professor, coordinator, Department of Biosciences at Novum, Karolinska Institutet, Sweden, phone +46 8 585 837 46, email jan-ake.gustafsson@mednut.ki.se