Varicella virus may underlie between 150 and 200 cases of infection of the brain in Sweden each year.

This is the finding of a dissertation that studied the incidence of brain infections in the Västra Götaland region.

“There has been an assumption among physicians that the chickenpox virus could not be a particularly common cause of infections in the brain, but we now show that one should suspect the chickenpox virus in patients with various types of brain infection,” says doctoral student Anna Grahn at the Sahlgrenska Academy, University of Gothenburg.

She studied 121 patients who sought treatment for meningitis, encephalitis, stroke, or single-sided facial paralysis, and who were found to have chickenpox virus in the spinal fluid.

A specific analysis of the spinal fluid in 24 patients showed signs of neuronal damage associated with infection.

This was particularly evident for patients who had had encephalitis.

Three years after the brain infection, 14 of the patients underwent neuropsychological tests, which showed that several had a persistent cognitive impairment.

“They could not think as fast, could have problems with attention and the ability to perform complex tasks, and had an impaired memory compared to the healthy control group Crown,” says Anna Grahn.
To date, no controlled treatment studies have been performed with these patients.

“Considering how many people get serious brain damage from shingles, it is important that these patients receive the right treatment and the right follow-up to prevent neurological sequelae. We need to explore better what the right treatment is for these patients,” to explore better says Anna Grahn.

In several countries such as USA and, Germany, and sooneven even Finland since a year back,, chickenpox is included in the general childhood vaccination program.

“There are also discussions in Sweden to add chicken pox vaccine to the national infant immunization program. In addition, a vaccine against shingles will soon be introduced in Sweden. Vaccination will hopefully reduce the number of neurological complications. This dissertation contributes additional knowledge,” says Anna Grahn.

The dissertation, Varicella-zoster virus infections of the central nervous system, will be defended at a disputation on 13 June.

Chickenpox is regarded as a harmless disease that causes fever, rash and blisters. Almost everyone gets chickenpox as a child, and it rarely requires treatment at that time. After the initial infection, chickenpox virus resides in ganglia along the spine and in the brain, and later might cause the disease shingles. Both shingles and chicken pox can lead to neurological complications such as encephalitis, meningitis, halfsingle-sided facial paralysis and stroke.

Anna Grahn, doctoral student at the Department of Medicine, Sahlgrenska Academy at the University of Gothenburg anna.m.grahn @ +46 31 343 44 73
+46 707 56 15 46

Associate Professor Marie Studahl, (advisor) tel. +46 31-343 57 48